Principal Investigator Training & Certification Tuition

Enroll Risk-Free in CCRPS Advanced PI Training with 100% Money-back guarantee. See why thousands of alumni choose us below.

Advanced PI Certification | Expert-Led Online PI Training

Novel Principal Investigator Training for 2025 

Bridge Knowledge Gaps With Advanced PI Training

Complex Trials & Rigorous Regulations

  • Excessive paperwork & confusing FDA/IRB standards
  • Recruitment challenges & team management issues
  • Missed funding and trial opportunities
  • Regulatory uncertainty and compliance risks

Improve Your Site and Trial Outcomes

With Proven, Expert-Led Training

  • Master 150+ PI topics with 170 advanced modules
  • Accelerate your career & boost earnings significantly
  • Earn CPD-accredited recognition and a prestigious certification
  • Receive free training for your research coordinator
  • Enjoy flexible, self-paced online learning with lifetime access

Why Become a Certified Principal Investigator? Your Benefits:

Why Get Advanced Principal Investigator Training? 

📘
Master Every Domain
Comprehensive Expertise – Gain mastery over all 284 topics of the PI role, from trial design to patient safety. With 170+ advanced modules, confidently tackle regulatory challenges and data management. Lifetime access ensures you always stay current.
📈
Advance Your Career & Earnings
Accelerated Career Growth – Certification opens the door to senior roles and higher income potential. Alumni report salary increases of $39K–$259K+, positioning you as a leader recognized by top research organizations.
🎖️
Gain Credibility & Recognition
Earn Trust & CPD Accreditation – Our certification is CPD-accredited, ensuring your training meets rigorous standards. Earn CPD credits, a digital certificate, and a LinkedIn badge that solidify your status as an expert in clinical research.
👥
Empower Your Team
Free Training for Coordinators – Enroll now to receive complimentary training for your clinical research coordinator. Equip your team with best practices to boost trial efficiency and compliance.
💻
Flexible Learning
Physician-Friendly & Convenient – Enjoy 100% online, self-paced learning with lifetime access to all course materials. Learn on your schedule, whether in the clinic or at home.
🌟
Trusted by Leading PIs
Utilized by top Principal Investigators nationwide, our program is renowned for its in-depth, practical content that transforms clinical research careers. Join a community of experts who consistently deliver outstanding trial outcomes.

What Our PI Alumni Are Saying

Advanced Principal Investigator Certification Testimonials

5 star rating

APIPC Course

ROGER ANDERSEN

Course is excellent for covering the key areas that a PI needs to be familiar with.

Course is excellent for covering the key areas that a PI needs to be familiar with.

Read Less
5 star rating

Introduction

Eneida Roldan

The introduction and steps to prepare for the modules, achieving success, and certification were very well developed. Excellent introduction.

The introduction and steps to prepare for the modules, achieving success, and certification were very well developed. Excellent introduction.

Read Less
5 star rating

Advanced Research Principal Investigator Certification (APIPC)

Liliana Ruiz-Leon

Great Course that was very helpful to my career as a Principal Investigator.

Great Course that was very helpful to my career as a Principal Investigator.

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5 star rating

A good training

Zaid Seni

Its a comprehensive training with fair amounto of details

Its a comprehensive training with fair amounto of details

Read Less
5 star rating

Very good Lt

Dr. Bill Akpinar

Good

Advanced PI Certification Comparison & Pricing

How Our PI Program Stands Out

Compare the unique features of our PI Masterclass™ and PI Executive Fellowship™ programs.

Accredited & Comprehensive

Earn CPD accreditation plus 17.5 AMA CME credits and master 171 modules across 284 topics.

Available in:
PI Masterclass™
PI Executive Fellowship™

Flexible & Self-Paced

Access 100% online training anytime, anywhere to suit your busy schedule.

Available in:
Both Tiers

Advanced Mentorship

Group webinars in Masterclass™ or 1-on-1 sessions in Fellowship™ with senior experts.

Available in:
Masterclass™ (Group)
Fellowship™ (Private)

Regulatory Guidance

Learn advanced strategies for FDA, EMA, HIPAA, and global regulations with personalized reviews.

Available in:
Masterclass™
Fellowship™ (2 Expert Reviews)

Team & Growth Strategy

Free CRC training plus strategic sessions for site selections and trial growth.

Available in:
Masterclass™ (1 CRC)
Fellowship™ (3 Staff + Strategy)

Guaranteed Success

Transform your PI career and earn $39k–$259k more with our proven program and 14-day refund guarantee.

Available in:
Both Tiers

Program Tiers & Payment Plans

PI Masterclass™
Advanced PI Training & Certification
$1,499
or 3 x $500/mo
  • 171 advanced modules
  • CPD + 17.5 AMA CME credits
  • 50-question exam, digital certificate & LinkedIn badge
  • Free CRC training for 1 coordinator
  • 24/7 support & group mentorship
  • Money-back guarantee
Enroll Now - Instant Access
PI Executive Fellowship™
Ultimate Mentorship & Leadership
$2,499
or 5 x $500/mo
  • Everything in Masterclass™
  • 6 private mentorship sessions
  • Protocol & study design review
  • Capstone project spotlight
  • 2 strategic sessions for growth
  • Money-back guarantee
Enroll Now - Instant Access
Achieve Excellence as a Research Principal Investigator. Earn $39k–$259k more with advanced PI certification. Master efficient trials, compliance, and secure more site selections. 100% Money-back Guarantee with a 14-Day Refund Policy. Payment Plans Available.

Advanced PI Certification Syllabus

Comprehensive PI Training Syllabus

Course Highlights

  • Expert-led curriculum covering critical PI competencies
  • Comprehensive PI toolkit & foundations
  • Master clinical trial design & regulatory strategy
  • Leadership & team management skills
  • Data management & quality assurance training
  • Lifetime access & alumni network

Example Modules

  • Introduction & ARPIC Overview
  • PI Toolkit, GCP, FDA Forms & IRB Essentials
  • Advanced Trial Design & Protocol Development
  • Investigator & Team Leadership Strategies
  • Documents, Informed Consent & Regulatory Docs
  • Site Visits, Audits & Adverse Event Management, & more

Dynamic Learning Tools

  • Interactive case simulations
  • Application-based virtual labs
  • Live webinars & peer review sessions
  • Mobile learning apps
  • Real-time regulatory updates & forums
  • One-on-one mentorship sessions

Principal Investigator Training

Advanced Principal Investigator Physician Certification (ARPIC) Syllabus

    1. Introduction to the Advanced Principal Investigator Certification (ARPIC)

      FREE PREVIEW
    2. How to Use PI Course / CME Handout

    3. Live Review Webinar - See discussion for next meeting date

    1. Principal Investigator Toolkit

    2. Principal Investigators Roles, Checklists, & GCP Guidelines

    3. Principal Investigators Reporting Responsibilities for AEs and SAEs

    4. FDA Form 1572

    5. Evolution of the Principal Investigator Role in Modern Clinical Trials

    6. Ethical Standards in Human Research

    7. Understanding and Applying Good Clinical Practice (ICH-GCP) Principles

    8. Role of Principal Investigators in Ensuring Oversight and Compliance in Trials

    9. Investigator-Initiated Trials (IITs) vs. Sponsor-Initiated Trials (SITs)

    10. 21 CFR Regulations - Legal and Ethical Accountability in Complex Clinical Trial Setups

    11. Coordination of Multidisciplinary Collaboration for Comprehensive Trial Oversight

    12. Crafting Sponsorship Agreements and Negotiating Key Investigator Obligations

    13. Institutional Review Board (IRB) and Ethics Committee Processes – Global Variations

    14. Ethical Frameworks for High-Risk and Complex Clinical Research Studies

    15. Investigator Responsibilities for Multinational and Multicenter Clinical Trials

    16. Investigational product (IP) accountability, storage, and dispensing

    17. Investigator-Initiated Multi-Center Trials

    1. Advanced Review of Phases of Clinical Trials (Preclinical & Phase 0-4)

    2. Advanced Designs of Clinical Trials

    3. Institutional Review Board/Ethics Committee (IRB/EC) (Requirements, sIRB, Application, Exemptions, Expedited Review, Continuation, and Reporting)

    4. Randomized Controlled Trials (Randomization, Allocation Concealment, Validity, Blinding, Controls, Outcomes, Fidelity)

    5. The Clinical Trial Protocol - Advanced Mastery Review

      FREE PREVIEW
    6. Protocol Deviations and Violations (Major, Minor, Exceptions, Resolution)

    7. Inclusion and Exclusion Criteria in Clinical Research (Writing, Assessing for Broad vs. Narrow, Organ Dysfunction, Older Adults, Pediatrics, Pregnant Women)

    8. Design of Translational Research Protocols for Early-Phase Studies

    9. Adaptive and Decentralized Trial Designs for Modern Research Needs

    10. Protocol Development for Rare Diseases, Orphan Drugs, and Small Patient Populations

    11. Pediatric Clinical Trials – Ethical and Design Considerations

    12. Designing Clinical Research Studies for Vulnerable Patient Populations

    13. Best Practices for International Multisite Clinical Trials

    14. Behavioral and Psychiatric Research Study Designs

    15. Robust Protocol Management for First-in-Human (FIH) Trials

    16. Medical Device Clinical Trials – Unique Design and Regulatory Factors

    1. Building and Leading Multidisciplinary Research Teams Across Borders

    2. Delegation of Responsibilities to Sub-Investigators and Support Teams

    3. Site Selection Strategies for Diverse International Trials

    4. Training International Research Teams for Protocol Compliance

    5. Coordinating Corrective and Preventive Action Plans (CAPA) for International Non-Compliance

    6. Leadership Strategies for Multi-Site, Cross-Cultural Clinical Trials

    7. Sponsor-PI Communication for Efficient International Collaboration

    1. Informed Consent (ICH GCP Section 4.8)

    2. Trial Management, Data Handling, and Record Keeping

    3. Compliance with E-Signatures CFR 21 Part 11

    4. Essential Regulatory Documents Guidance and Binder Tabs

    5. Guidelines for Designing and Completing Case Report Forms

    6. Do’s and Don’ts of a Case Report Form Design

    7. Investigators Brochures

    8. Trial Master File and DIA Model

    9. Trial Master File Reference Guide

    10. Financial Disclosures and Conflicts of Interest

    1. Types of Monitoring Visits (Selection, Initiation, Routine, Close-Out)

    2. Site and Investigator Selection Criteria (Process, Criteria, Investigator Selection, Agreements, Decision-Making)

    3. Site Selection/Qualification Pre-Study Visit (SSV/SQV) (Before, During, After, Letters, Checklists, and Report)

    4. Site Initiation Visit (SIV) (Before, During, After, Letters, Checklists, and Report) - Review from "Types of Monitoring Visits"

    5. Routine/Interim/Periodic Monitoring Visit (RMV/IMV/PMV) (Before, During, After, Remote, Letters, Checklists, and Report)

    6. Site Close Out Visit (Before, During, After, Early Termination, Letters, Checklists, and Report)

About this course

  • $500.00
  • 171 lessons
  • Lead Clinical Trials. 17.5 CME.
  • MD/PhD, PI, or Sub-Is can enroll.
  • Salary range $112k-269k+.

Alumni Success Stories | Advanced PI Certification

Data-Driven Graduate Success 

Diverse Backgrounds

Students came from various CROs, universities, hospitals, clinics, and clinical research sites, etc.‡

A wealth of experience fueling clinical innovation.

Alumni Work At

Graduates worked at Accelemed Research, Zion Healthcare, CAP Research, Quotient Sciences, Profil Institut für Stoffwechselforschung GmbH, Physician Affiliate Group of New York, San Carlos Apache Healthcare Corporation, DBA Cairn Diagnostics, IMA Research Austin Group, Lucas Research, etc.‡

Trusted by top-tier institutions nationwide.

Alumni Job Titles

Graduates obtained roles including Principal Investigator in Clinical Research, Principal Research Investigator, Senior Clinical Research Investigator, Clinical Research Director, etc.

Leading roles that shape the future of clinical research.

Advanced PI Certification | Course Features & Pricing

Course Features

  • Principal Investigator Toolkit, Foundations, Clinical Trial Design, and Protocol Development
  • Investigator and Team Leadership, Documents & Informed Consent, Site Visits and Audits
  • Patient Safety, Recruitment, and Compliance, Regulatory Compliance and Ethical Frameworks, Adverse Events, Monitoring, and Quality Assurance
  • Advanced Data and Document Management, Comprehensive Clinical Trial Niches for PIs, International Clinical Trial Mastery
  • Medical Device Clinical Research, Technologies and Innovations in Research Leadership, Final Review & APIPC Certification Exam

Pricing & Enrollment

3x $500
$1899 Value. In-Depth PI Training Program. 100% Money-back guarantee.
Become An Advanced PI
$1,499.00
PI Oversight Masterclass™
Enroll Now - Instant Access
$2,499.00
PI Executive Fellowship™
Enroll Now - Instant Access
$5,000.00 / year
Organizational APIPC Licensing
Request Demo

How It Works: Step-by-Step to Certification

How It Works: Step-by-Step to Certification

Step 1: Enroll

Choose your enrollment tier (Masterclass™ or Fellowship™) and begin instantly with full access. Financing options via Klarna, Affirm, or in-house plans are available.

Step 2: Study Your Way

Access 171+ modules, interactive case simulations, webinars, and downloadable study tools. Follow our structured path—or skip non-essential modules and focus on the study guide.

Step 3: Set Your Pace

Choose your path: Full Completion (174 hours) for mastery, or Fast Track (skim + study guide) to certify in 1–2 weeks. You control your timeline.

Step 4: Certify & Update

Pass the open-book final exam (2 attempts) to earn your 17.5 CME credits and CPD hours. Instantly download your certificate and activate your LinkedIn badge.

FAQ | Advanced PI Certification

Frequently Asked Questions about ARPIC

1. What is the Advanced Principal Investigator Physician Certification (ARPIC)?

The ARPIC is a 100% online, self-paced, CME/CPD-accredited training program designed to equip physicians and research professionals with mastery in over 284 Principal Investigator topics. With 171 advanced modules and expert-led instruction, it prepares you to lead clinical trials, ensure compliance, and secure top-tier site selections.

2. Who should enroll in the ARPIC course?

This course is ideal for active or aspiring Principal Investigators including MDs, DOs, PharmDs, PhDs, PAs, and NPs looking to advance in clinical research. Sub-Investigators and site directors transitioning to PI roles will benefit greatly.

3. What certificate do I receive?

Graduates receive: 17.5 AMA PRA Category 1 CME Credits™, 50+ CPD hours, a digital ARPIC certificate, a LinkedIn badge, and lifetime access to all learning materials and updates.

4. Is this course accredited?

Yes. ARPIC is accredited and recognized by the Accreditation Council for Continuing Medical Education (ACCME) for CME via PIMED) and global CPD standards.

5. How long does it take to complete the course?

The full course includes 174 hours of content. Most professionals complete it in 1–4 weeks. You may skip modules less relevant to your experience and focus on the study guide and final exam.

6. What topics are covered in the ARPIC syllabus?

Key topics are too long to list here (see syllabus above for a full list) but include: PI Toolkit & Foundations, Clinical Trial Design & Protocol Development, Investigator & Team Leadership, Informed Consent & Regulatory Documents, Audits, Adverse Event Reporting & Compliance, Data & Document Management, Global Clinical Trial Mastery, and Medical Devices & Innovation.

7. How is the course delivered?

The program is fully online and mobile-friendly. It includes interactive case simulations, virtual labs, optional live webinars, regulatory updates, and optional one-on-one mentorship.

8. Is mentorship included?

Mentorship is included in the PI Executive Fellowship™ tier. You’ll receive six 1:1 private sessions, protocol design review, and two strategic growth consults.

9. What enrollment options are available?

Options include:
• PI Masterclass™ – $1,499 (or 3 x $500)
• PI Executive Fellowship™ – $2,499 (or 10 x $500)
• Organizational Licensing – $5,000/year

10. Are payment plans available?

Yes. We offer in-house split payments (e.g., 3 x $500) and financing via Klarna and Affirm. You can enroll immediately and pay over time.

11. What support is available during the course?

You have access to 24/7 technical support, mentorship (depending on tier), and a private student forum for peer and expert discussions.

12. How is the final exam structured?

The certification exam includes 50 multiple-choice questions based on the study guide. A passing score of 70% is required, and two attempts are included.

13. Do I get a study guide?

Yes. A downloadable 50+ page study guide is provided, summarizing all core modules to help you prepare efficiently for the final exam.

14. What if I don’t pass the exam on the first try?

You have up to two attempts to pass. Most learners succeed on their first attempt with the help of the study guide.

15. Can I access the materials after completing the course?

Yes. You’ll receive lifetime access to the full course, including all future updates, webinars, and bonus modules.

16. Is CRC training included?

Yes. Every enrollment includes one free Clinical Research Coordinator (CRC) training seat to ensure your site team is trained and aligned.

17. How does this course help with sponsor and CRO site selection?

This course strengthens your feasibility assessments, site performance, and documentation—ensuring you become an audit-ready, compliant PI trusted by sponsors with the knowledge to support your site.

18. How does this course impact my career and salary?

Graduates have reported salary increases of $39K–$259K+ and secured roles such as Senior Clinical Investigator, Clinical Research Director, and more.

19. Is the training applicable to international trials?

Yes. ARPIC is built on FDA, ICH E6(R2), E8, EMA, and global regulatory frameworks, making it suitable for U.S. and international trials.

20. Does the course include practical tools?

Yes. You’ll receive downloadable templates for delegation logs, protocol tools, audit prep checklists, visit reports, and more.

21. Can I use this course for GCP documentation during audits?

Yes. Your certificate, transcript, and completed modules meet sponsor and IRB expectations for PI training and ISF documentation.

22. Can I preview the course before enrolling?

Yes. You can access a free preview module before full enrollment to see if the format and content match your needs.

23. What kind of roles have alumni obtained?

Graduates have transitioned into roles such as Principal Investigator, Senior Research Investigator, Clinical Research Director, Lead Investigator at academic and private institutions, and more.

24. Is there a satisfaction guarantee?

Yes. All enrollments come with a 14-day money-back guarantee. If the course doesn’t meet your expectations, you’ll receive a full refund.

25. How do I enroll and get started?

Scroll above and choose your preferred tier. Once enrolled, you’ll receive instant access to the course dashboard, study guide, and first lessons.