Principal Investigator Training & Certification Tuition

Accredited and Industry-recognized PI certification with unmatched curriculum. 100+ new lessons for 2025 to stay ahead and stand out. Increase salary potential by $30-200k+. Proven Grad Success for 8 Years. 100% Money-back Guarantee with 14 Day Refund Policy. Payment Plans Available.

  • $500.00

    ($1000 Value) 171 Advanced PI Training Modules + Certification & LinkedIn Badge. CPD + CME Credits. Lifetime access to unmatched curriculum.

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Principal Investigator Training

Advanced Principal Investigator Physician Certification (ARPIC) Syllabus

    1. Advanced Principal Investigator Training Overview

      FREE PREVIEW

    2. School Policy and Student Enrollment Agreement

    3. What To Expect

      FREE PREVIEW

    4. PI Course Orientation & 24/7 Support Center

    5. ARPIC Course Syllabus and Schedule

    6. PI Professional Advancement Workshop - Upload New Resume/LinkedIn Profile

    7. Principal Investigator Career Advancement Toolkit

    8. Accelerated 21 Day PI Career Pathway and Course Outline

    9. Live Review Webinar Review Questions - You Will Be Emailed The Next Meeting Date

    1. Principal Investigators Roles, Checklists, & GCP Guidelines

    2. FDA Form 1572

    3. Evolution of the Principal Investigator Role in Modern Clinical Trials

    4. Ethical Standards in Human Research

    5. Understanding and Applying Good Clinical Practice (ICH-GCP) Principles

    6. Role of Principal Investigators in Ensuring Oversight and Compliance in Trials

    7. Investigator-Initiated Trials (IITs) vs. Sponsor-Initiated Trials (SITs)

    8. 21 CFR Regulations - Legal and Ethical Accountability in Complex Clinical Trial Setups

    9. Coordination of Multidisciplinary Collaboration for Comprehensive Trial Oversight

    10. Crafting Sponsorship Agreements and Negotiating Key Investigator Obligations

    11. Institutional Review Board (IRB) and Ethics Committee Processes – Global Variations

    12. Ethical Frameworks for High-Risk and Complex Clinical Research Studies

    13. Investigator Responsibilities for Multinational and Multicenter Clinical Trials

    14. Investigational product (IP) accountability, storage, and dispensing

    15. Investigator-Initiated Multi-Center Trials

    1. Advanced Review of Phases of Clinical Trials (Preclinical & Phase 0-4)

    2. Advanced Designs of Clinical Trials

    3. The Clinical Trial Protocol - Advanced Mastery Review

    4. Institutional Review Board/Ethics Committee (IRB/EC) (Requirements, sIRB, Application, Exemptions, Expedited Review, Continuation, and Reporting)

    5. Randomized Controlled Trials (Randomization, Allocation Concealment, Validity, Blinding, Controls, Outcomes, Fidelity)

    6. Inclusion and Exclusion Criteria in Clinical Research (Writing, Assessing for Broad vs. Narrow, Organ Dysfunction, Older Adults, Pediatrics, Pregnant Women)

      FREE PREVIEW

    7. Design of Translational Research Protocols for Early-Phase Studies

    8. Adaptive and Decentralized Trial Designs for Modern Research Needs

    9. Protocol Development for Rare Diseases, Orphan Drugs, and Small Patient Populations

    10. Pediatric Clinical Trials – Ethical and Design Considerations

    11. Designing Clinical Research Studies for Vulnerable Patient Populations

    12. Best Practices for International Multisite Clinical Trials

    13. Behavioral and Psychiatric Research Study Designs

    14. Robust Protocol Management for First-in-Human (FIH) Trials

    15. Medical Device Clinical Trials – Unique Design and Regulatory Factors

    1. Building and Leading Multidisciplinary Research Teams Across Borders

    2. Delegation of Responsibilities to Sub-Investigators and Support Teams

    3. Site Selection Strategies for Diverse International Trials

    4. Training International Research Teams for Protocol Compliance

    5. Coordinating Corrective and Preventive Action Plans (CAPA) for International Non-Compliance

    6. Leadership Strategies for Multi-Site, Cross-Cultural Clinical Trials

    7. Sponsor-PI Communication for Efficient International Collaboration

    1. Informed Consent (ICH GCP Section 4.8)

    2. Trial Management, Data Handling, and Record Keeping

    3. Compliance with E-Signatures CFR 21 Part 11

    4. Essential Regulatory Documents Guidance and Binder Tabs

    5. Guidelines for Designing and Completing Case Report Forms

    6. Do’s and Don’ts of a Case Report Form Design

    7. Investigators Brochures

    8. Trial Master File and DIA Model

    9. Trial Master File Reference Guide

    10. Financial Disclosures and Conflicts of Interest

    1. Types of Monitoring Visits (Selection, Initiation, Routine, Close-Out)

    2. Site and Investigator Selection Criteria (Process, Criteria, Investigator Selection, Agreements, Decision-Making)

    3. Site Selection/Qualification Pre-Study Visit (SSV/SQV) (Before, During, After, Letters, Checklists, and Report)

    4. Site Initiation Visit (SIV) (Before, During, After, Letters, Checklists, and Report) - Review from "Types of Monitoring Visits"

    5. Routine/Interim/Periodic Monitoring Visit (RMV/IMV/PMV) (Before, During, After, Remote, Letters, Checklists, and Report)

    6. Site Close Out Visit (Before, During, After, Early Termination, Letters, Checklists, and Report)

About this course

  • $500.00
  • 177 lessons
  • Lead Clinical Trials. 17.5 CME.
  • MD/PhD, PI, or Sub-Is can enroll.
  • Salary range $112k-269k+.
5 star rating

Advanced Research Principal Investigator Certification (APIPC)

Liliana Ruiz-Leon

Great Course that was very helpful to my career as a Principal Investigator.

Great Course that was very helpful to my career as a Principal Investigator.

Read Less
5 star rating

APIPC Course

ROGER ANDERSEN

Course is excellent for covering the key areas that a PI needs to be familiar with.

Course is excellent for covering the key areas that a PI needs to be familiar with.

Read Less
5 star rating

Introduction

Eneida Roldan

The introduction and steps to prepare for the modules, achieving success, and certification were very well developed. Excellent introduction.

The introduction and steps to prepare for the modules, achieving success, and certification were very well developed. Excellent introduction.

Read Less

Principal Investigator Training Overview

In-Depth Skills & Objectives for Each PI Training Chapter

Chapter & Lessons Objectives & PI Skills
Introduction: Advanced Principal Investigator Training Overview; School Policy & Enrollment Agreement; What to Expect; PI Orientation & 24/7 Support; Syllabus & Schedule; PI Career Advancement Toolkit; Accelerated 21‑Day Career Pathway; Live Review Webinar Questions Acquaint PIs with program structure, certification roadmap, and professional development resources; prepare for continuous support and career advancement.
CH 1. PI Toolkit & Foundations: PI Roles, Checklists & GCP Guidelines; FDA Form 1572; Evolution of PI Role; Ethical Standards; ICH‑GCP Principles; Oversight & Compliance; IITs vs. SITs; 21 CFR Regulations; Multidisciplinary Collaboration; Sponsorship Agreements & Negotiation; IRB/EC Processes (Global Variations); Ethical Frameworks for Complex Studies; PI Responsibilities in Multinational Trials; IP Accountability & Storage; IIT Multi‑Center Trials Master core PI responsibilities: regulatory compliance (Form 1572, 21 CFR), GCP oversight, ethical conduct, IRB navigation, sponsor‑PI negotiations, IP management, and leadership in multi‑center and investigator‑initiated trials.
CH 2. Clinical Trial Design & Protocol Development: Phases 0–IV Review; Advanced & Adaptive Designs; Protocol Mastery; IRB/EC Requirements; RCT Methodologies; Inclusion/Exclusion Criteria; Translational Research Protocols; Decentralized & Rare‑Disease Design; Pediatric & Vulnerable‑Population Studies; International Multisite Best Practices; Behavioral & Psychiatric Protocols; FIH Trial Management; Medical Device Trial Design Develop PI expertise in protocol crafting, study design (adaptive, decentralized, FIH), RCT methodology, eligibility criteria, and specialized trial types (pediatric, orphan, device), ensuring ethical and scientific rigor across populations and geographies.
CH 3. Investigator & Team Leadership: Building & Leading Research Teams; Delegation to Sub‑Investigators; Site Selection Strategies; International Team Training; CAPA Coordination; Cross‑Cultural Leadership; Sponsor‑PI Collaboration Cultivate PI leadership skills: team formation, delegation, site feasibility assessment, CAPA management, cross‑cultural communication, and effective sponsor engagement for global trial execution.
CH 4. Documents & Informed Consent: ICH GCP Section 4.8 Informed Consent; Trial Management, Data Handling & Record Keeping; CFR 21 Part 11 E‑Signatures; Regulatory Binder Guidance; CRF Design Guidelines; Investigator’s Brochures; TMF & DIA Model; TMF Reference Guide; Financial Disclosures & COI Equip PIs to oversee informed consent processes, maintain e‑compliance, design CRFs, manage TMF, and handle financial‑disclosure requirements with ethical and regulatory precision.
CH 5. Site Visits & Audits: Monitoring Visit Types; Site/Investigator Selection Criteria; SSV/SQV Procedures; SIV Procedures; RMV/IMV/PMV Procedures; SCOV Procedures Strengthen PI oversight during site qualification, initiation, routine and close‑out visits; interpret monitoring findings and ensure audit readiness.
CH 6. Patient Safety, Recruitment & Compliance: ICH GCP History; Patient Recruitment Strategies; Engagement & Retention; Adherence Monitoring; Human‑Subject Safety; Ethics for Special Populations Equip PIs to develop recruitment/retention plans, monitor adherence, safeguard vulnerable subjects, and uphold safety standards in trial populations.
CH 7. Regulatory Compliance & Ethics: PI Reporting for AEs/SAEs; IND/CTA/IDE Submissions; Global Compliance Challenges; Privacy & Data Security; Expanded Access Ethics; AE/SAE Reporting; Protocol Deviations Management; DSMB Roles; Trial Registries; Conflict‑of‑Interest Mitigation; Research Integrity Advance PI capabilities in safety reporting, regulatory submission preparation, data‑privacy compliance, registry maintenance, conflict‑management, and ethical oversight of expanded access and international investigations.
CH 8. AEs, Monitoring & QA: Advanced AE Review; Risk‑Based Monitoring; SDV Oversight; Remote Monitoring; Data Consistency; Digital Oversight Platforms; Site Monitoring Plans; Vendor QA; Regulatory Audit Preparation; Medical Device Safety Monitoring Develop PI mastery in AE assessment, implement risk‑based and remote monitoring, ensure data quality, manage vendor relationships, and prepare for regulatory inspections.
CH 9. Advanced Data & Document Management: Protocol Deviations & Resolution; EDC Fundamentals; Data Validation & Query Resolution; Privacy Laws (HIPAA/GDPR); Audit‑Readiness Documentation; Data Standardization; Missing Data Handling Strengthen PI proficiency in EDC, data integrity, global privacy compliance, audit‑ready documentation, and handling deviations and missing data in multi‑site trials.
CH 10. Clinical Trial Niches for PIs: Oncology; Neurology; Cardiology; Pulmonology; Gastroenterology; Dermatology; Rheumatology; Endocrinology; Infectious Diseases; Rare Diseases; Pediatrics; Psychiatry; Geriatrics; Nephrology; Hematology; Ophthalmology; Addiction Medicine; Devices; Regenerative Medicine; Telemedicine; Pharmacogenomics; Trauma; Vaccinology; Transplant; Immunotherapy; Sleep Medicine; Psychopharmacology; Perioperative; Imaging; Women’s Health; Fertility; Palliative Care; Environmental Medicine; Gastrointestinal Cancers; Pediatric Rare Syndromes; Sports Medicine; Longevity; Nutrition; Space Medicine; Biomarker Discovery; Post‑Infection Syndromes; Rare Neuromuscular Disorders; Preventative Cardiology; Healthcare Disparities; Autoimmune Neurology; Neuro‑Oncology; Wound Care; Emergency Preparedness; Pediatric Cardiology; Dental & Oral Health; Occupational Health; Behavioral Medicine; Robotics in Surgery; Neonatal Trials; Interstitial Lung Disease; Migraine; End‑of‑Life Care; Medical Genetics; Veteran Health; Ototoxicity; Health Tech Validation; Neurodevelopmental Disorders Equip PIs with specialized knowledge across a vast array of therapeutic and technological domains, enabling protocol design, oversight, and scientific leadership in niche and emerging research areas.
CH 11. International Trial Mastery: Global Regulatory Variations (FDA, EMA, PMDA, ICMR); Emerging Markets & LMIC Challenges; Diverse Population Recruitment; Global Logistics & IP Supply; Multinational Compliance Develop PI expertise in navigating diverse regulatory frameworks, cultural recruitment strategies, supply‑chain logistics, and adapting compliance protocols for global, resource‑limited settings.
CH 12. Medical Device Clinical Research: FDA IDE; EU MDR; ISO Standards; Post‑Market Surveillance; Human Factor Studies; Non‑Invasive Remote Monitoring Trials Advance PI skills in device‑trial design, regulatory submissions, human factors evaluation, and remote monitoring methodologies for medical devices.
CH 13. Research Technologies & Innovation: Blockchain for Data Security; Wearables & Telemetry in Remote Trials; Gene‑Editing Protocols Build PI competence in emerging research technologies, blockchain, wearables, telemetry, and gene‑editing to secure data and support innovative trial designs.
Final Review & ARPIC Exam: PI Exam Study Guide; ARPIC Certification Exam (50 Questions); 17.5 CME Handout Validate comprehensive PI competencies via study guide and certification exam; consolidate learning and secure CME credits.

Take the role-specific multi-specialty training program utilized by PIs to advance themselves and their site

Get Cutting-Edge Principal Investigator Training

CPD & CME Accredited. 14 day refund policy. 24/7 support. 8 years of grad success.

Compare Principal Investigator Training Programs

Set the standard for success at your site with ARPIC


Provider / Course Core Offering & Credentials Price + Renewal & Key Pros / Cons
CCRPS – ARPIC™ Advanced Principal Investigator Physician Certification • 171 modules across 13 chapters • 17.5 AMA CME + 170 CPD hours • 50-question proctored exam • Digital certificate + LinkedIn badge • Triple-accredited • Lifetime access • Includes 1 free CRC training for team support $500 Pros: most comprehensive CPD accredited PI certification at accessible price; covers site leadership, ethics, protocol writing, GCP, decentralized and device trials; flexible self-paced format; 14-day refund policy Cons: heavier content load (~174 hours)
Academic PI Training Program • 8-week program (~40–60 hours) • Certificate of completion • Recorded lectures, discussion boards • Basic GCP, protocol design, team management $2,000–$2,800 Pros: strong academic foundation; university brand credibility Cons: lacks CPD/CME; limited hands-on tools; no lifetime access or post-course mentorship
Sponsor-Based PI Training Course • Sponsor-mandated content for investigator qualification • Covers FDA Form 1572, ICH-GCP, protocol adherence • No portable certificate or exam Free (included with trial participation) Pros: convenient and role-specific; fulfills immediate sponsor requirements Cons: non-transferable credential; limited depth; lacks leadership, multi-trial, or global trial training
Short-Format Industry PI Program • GCP and trial oversight essentials • 10–12 hours of content • Completion certificate only • No live faculty or custom mentoring ~$699 Pros: quick compliance refresher; accessible online format Cons: lacks advanced topics (e.g., protocol design, multicenter trial management); no credential portability or CME credits

What Our PI Alumni Are Saying

5 star rating

Introduction

Eneida Roldan

The introduction and steps to prepare for the modules, achieving success, and certification were very well developed. Excellent introduction.

The introduction and steps to prepare for the modules, achieving success, and certification were very well developed. Excellent introduction.

Read Less
5 star rating

Very good Lt

Dr. Bill Akpinar

Good

Good

Read Less
5 star rating

Great course

Anas Malik Radif Alubaidi

Insightful and informative course

Insightful and informative course

Read Less
5 star rating

Advanced Research Principal Investigator Certification (APIPC)

Liliana Ruiz-Leon

Great Course that was very helpful to my career as a Principal Investigator.

Great Course that was very helpful to my career as a Principal Investigator.

Read Less
5 star rating

A good training

Zaid Seni

Its a comprehensive training with fair amounto of details

Its a comprehensive training with fair amounto of details

Read Less

FAQs for Principal Investigator

Learn more about ARPIC


Question Answer
What is a principal investigator? A principal investigator is the lead researcher overseeing all aspects of a clinical trial. They are responsible for study design, participant safety, and regulatory compliance.
What is the definition of a principal investigator in research? A principal investigator (PI) is the individual responsible for the overall conduct, integrity, and success of a research study, often serving as the main contact with sponsors and IRBs.
How much do principal investigators make? PI salaries range from $112,000 to $250,000+, depending on specialty, funding, and trial complexity. The ARPIC certification can help unlock higher salary tiers.
How can I become a certified principal investigator? Enroll in the ARPIC program, complete the training modules, and pass the proctored 50-question exam. You’ll earn CME and CPD credits, a certificate, and a LinkedIn badge.
What does a principal investigator do day to day? PIs manage research teams, ensure protocol adherence, review data, handle compliance, and communicate with sponsors and oversight boards.
What’s the benefit of principal investigator certification? Certification provides formal recognition of your PI qualifications, improving credibility, site selection chances, and salary potential.
What’s included in the ARPIC principal investigator training? You’ll cover ethics, GCP, protocol design, audits, SAE reporting, medical device trials, data integrity, decentralized trials, and more.
Is ARPIC aligned with FDA, EMA, and NIH standards? Yes, the program adheres to global regulations including FDA, ICH-GCP, GDPR, HIPAA, and NIH funding standards.
What does the ARPIC exam involve? A 50-question, scenario-based exam. Passing score: 70%. Two attempts are included.
How long does the course take to complete? 2–4 weeks on average, self-paced. You have lifetime access to review and revisit material.
Is there mentorship included in ARPIC? While standard plans include community support, mentorship upgrades offer private coaching with certified PIs.
Can I use this for NIH-funded trials? Yes. The course includes modules on IND, IDE, grant compliance, and clinical trial registration—all NIH requirements.
Do I get support after I finish the course? Yes, you get lifetime access to updates and the option to return for refreshers. The certificate is permanently valid.
What if I’m already a principal investigator? ARPIC is a great way to formalize your experience, update your skills, and gain formal recognition that sponsors and IRBs respect.
What’s the difference between a PI and a co-principal investigator? A PI holds overall responsibility; co-principal investigators share duties, often in large or multicenter trials.
What are the software tools covered in this course? REDCap, Medidata, Veeva, CTMS, EDC platforms, TMF filing systems, and more.
Does this program help with audit preparation? Yes. You’ll learn site monitoring, inspection readiness, protocol deviation management, and data verification practices.
What kind of documentation will I learn to manage? Investigator Brochures, Case Report Forms (CRFs), Trial Master File (TMF), delegation logs, AE/SAE logs, and informed consent documents.
Is there a money-back guarantee? Yes, there’s a 14-day risk-free refund policy. No questions asked.
Are payment plans available? Yes. Split payment options are available via Klarna, Affirm, and in-house.
Is CRC training included? Yes. One free CRC training course is included to strengthen your site team.
Is the certification valid internationally? Yes, it’s recognized by international regulators, sponsors, and CROs across the U.S., EU, Asia, and beyond.
What makes ARPIC different from sponsor-required PI courses? ARPIC is portable across sponsors and offers real leadership training—not just GCP basics. It prepares you for long-term success as a PI.
Can I preview the course before enrolling? Yes. A free module preview is available so you can explore the format and curriculum.
What’s the role of a PI in a clinical trial? From start to finish, a PI is responsible for trial integrity, patient safety, regulatory submission, and successful study execution.
Do I get continuing medical education credit? Yes. You earn 17.5 AMA CME hours and 50+ CPD hours.
Does ARPIC help with job opportunities? Yes. Grads have secured roles at CROs, universities, and top health systems. Certification boosts recruiter and sponsor visibility.
Can this help me move into a director or leadership role? Definitely. Many PIs use ARPIC as a stepping stone to Clinical Research Director or Medical Monitor roles.
What happens if I don’t pass the exam the first time? You get a second attempt included, along with full access to study materials and support resources.
How do I enroll? Just click 'Enroll Now' on the course page. You’ll receive instant access, onboarding tools, and support to begin your certification journey.