Enroll Risk-Free in CCRPS Advanced PI Training with 100% Money-back guarantee. See why thousands of alumni choose us below.
($1299 Value, Reduced Fee Until May 1st) 124 Role-Specific Modules + Final Exam Study Guide + Certification/LinkedIn Badge.
PI Oversight Masterclass™
PI Executive Fellowship™
Organizational APIPC Licensing
Complex Trials & Rigorous Regulations
With Proven, Expert-Led Training
Advanced Principal Investigator Certification Testimonials
Course is excellent for covering the key areas that a PI needs to be familiar with.
Course is excellent for covering the key areas that a PI needs to be familiar with.
Read LessThe introduction and steps to prepare for the modules, achieving success, and certification were very well developed. Excellent introduction.
The introduction and steps to prepare for the modules, achieving success, and certification were very well developed. Excellent introduction.
Read LessGreat Course that was very helpful to my career as a Principal Investigator.
Great Course that was very helpful to my career as a Principal Investigator.
Read LessIts a comprehensive training with fair amounto of details
Its a comprehensive training with fair amounto of details
Read LessGood
Good
Read LessEarn CPD accreditation plus 17.5 AMA CME credits and master 171 modules across 284 topics.
Access 100% online training anytime, anywhere to suit your busy schedule.
Group webinars in Masterclass™ or 1-on-1 sessions in Fellowship™ with senior experts.
Learn advanced strategies for FDA, EMA, HIPAA, and global regulations with personalized reviews.
Free CRC training plus strategic sessions for site selections and trial growth.
Transform your PI career and earn $39k–$259k more with our proven program and 14-day refund guarantee.
Advanced Principal Investigator Physician Certification (ARPIC) Syllabus
Introduction to the Advanced Principal Investigator Certification (ARPIC)
FREE PREVIEWHow to Use PI Course / CME Handout
Live Review Webinar - See discussion for next meeting date
Principal Investigator Toolkit
Principal Investigators Roles, Checklists, & GCP Guidelines
Principal Investigators Reporting Responsibilities for AEs and SAEs
FDA Form 1572
Evolution of the Principal Investigator Role in Modern Clinical Trials
Ethical Standards in Human Research
Understanding and Applying Good Clinical Practice (ICH-GCP) Principles
Role of Principal Investigators in Ensuring Oversight and Compliance in Trials
Investigator-Initiated Trials (IITs) vs. Sponsor-Initiated Trials (SITs)
21 CFR Regulations - Legal and Ethical Accountability in Complex Clinical Trial Setups
Coordination of Multidisciplinary Collaboration for Comprehensive Trial Oversight
Crafting Sponsorship Agreements and Negotiating Key Investigator Obligations
Institutional Review Board (IRB) and Ethics Committee Processes – Global Variations
Ethical Frameworks for High-Risk and Complex Clinical Research Studies
Investigator Responsibilities for Multinational and Multicenter Clinical Trials
Investigational product (IP) accountability, storage, and dispensing
Investigator-Initiated Multi-Center Trials
Advanced Review of Phases of Clinical Trials (Preclinical & Phase 0-4)
Advanced Designs of Clinical Trials
Institutional Review Board/Ethics Committee (IRB/EC) (Requirements, sIRB, Application, Exemptions, Expedited Review, Continuation, and Reporting)
Randomized Controlled Trials (Randomization, Allocation Concealment, Validity, Blinding, Controls, Outcomes, Fidelity)
The Clinical Trial Protocol - Advanced Mastery Review
FREE PREVIEWProtocol Deviations and Violations (Major, Minor, Exceptions, Resolution)
Inclusion and Exclusion Criteria in Clinical Research (Writing, Assessing for Broad vs. Narrow, Organ Dysfunction, Older Adults, Pediatrics, Pregnant Women)
Design of Translational Research Protocols for Early-Phase Studies
Adaptive and Decentralized Trial Designs for Modern Research Needs
Protocol Development for Rare Diseases, Orphan Drugs, and Small Patient Populations
Pediatric Clinical Trials – Ethical and Design Considerations
Designing Clinical Research Studies for Vulnerable Patient Populations
Best Practices for International Multisite Clinical Trials
Behavioral and Psychiatric Research Study Designs
Robust Protocol Management for First-in-Human (FIH) Trials
Medical Device Clinical Trials – Unique Design and Regulatory Factors
Building and Leading Multidisciplinary Research Teams Across Borders
Delegation of Responsibilities to Sub-Investigators and Support Teams
Site Selection Strategies for Diverse International Trials
Training International Research Teams for Protocol Compliance
Coordinating Corrective and Preventive Action Plans (CAPA) for International Non-Compliance
Leadership Strategies for Multi-Site, Cross-Cultural Clinical Trials
Sponsor-PI Communication for Efficient International Collaboration
Informed Consent (ICH GCP Section 4.8)
Trial Management, Data Handling, and Record Keeping
Compliance with E-Signatures CFR 21 Part 11
Essential Regulatory Documents Guidance and Binder Tabs
Guidelines for Designing and Completing Case Report Forms
Do’s and Don’ts of a Case Report Form Design
Investigators Brochures
Trial Master File and DIA Model
Trial Master File Reference Guide
Financial Disclosures and Conflicts of Interest
Types of Monitoring Visits (Selection, Initiation, Routine, Close-Out)
Site and Investigator Selection Criteria (Process, Criteria, Investigator Selection, Agreements, Decision-Making)
Site Selection/Qualification Pre-Study Visit (SSV/SQV) (Before, During, After, Letters, Checklists, and Report)
Site Initiation Visit (SIV) (Before, During, After, Letters, Checklists, and Report) - Review from "Types of Monitoring Visits"
Routine/Interim/Periodic Monitoring Visit (RMV/IMV/PMV) (Before, During, After, Remote, Letters, Checklists, and Report)
Site Close Out Visit (Before, During, After, Early Termination, Letters, Checklists, and Report)
Students came from various CROs, universities, hospitals, clinics, and clinical research sites, etc.‡
Graduates worked at Accelemed Research, Zion Healthcare, CAP Research, Quotient Sciences, Profil Institut für Stoffwechselforschung GmbH, Physician Affiliate Group of New York, San Carlos Apache Healthcare Corporation, DBA Cairn Diagnostics, IMA Research Austin Group, Lucas Research, etc.‡
Graduates obtained roles including Principal Investigator in Clinical Research, Principal Research Investigator, Senior Clinical Research Investigator, Clinical Research Director, etc.
Choose your enrollment tier (Masterclass™ or Fellowship™) and begin instantly with full access. Financing options via Klarna, Affirm, or in-house plans are available.
Access 171+ modules, interactive case simulations, webinars, and downloadable study tools. Follow our structured path—or skip non-essential modules and focus on the study guide.
Choose your path: Full Completion (174 hours) for mastery, or Fast Track (skim + study guide) to certify in 1–2 weeks. You control your timeline.
Pass the open-book final exam (2 attempts) to earn your 17.5 CME credits and CPD hours. Instantly download your certificate and activate your LinkedIn badge.
The ARPIC is a 100% online, self-paced, CME/CPD-accredited training program designed to equip physicians and research professionals with mastery in over 284 Principal Investigator topics. With 171 advanced modules and expert-led instruction, it prepares you to lead clinical trials, ensure compliance, and secure top-tier site selections.
This course is ideal for active or aspiring Principal Investigators including MDs, DOs, PharmDs, PhDs, PAs, and NPs looking to advance in clinical research. Sub-Investigators and site directors transitioning to PI roles will benefit greatly.
Graduates receive: 17.5 AMA PRA Category 1 CME Credits™, 50+ CPD hours, a digital ARPIC certificate, a LinkedIn badge, and lifetime access to all learning materials and updates.
Yes. ARPIC is accredited and recognized by the Accreditation Council for Continuing Medical Education (ACCME) for CME via PIMED) and global CPD standards.
The full course includes 174 hours of content. Most professionals complete it in 1–4 weeks. You may skip modules less relevant to your experience and focus on the study guide and final exam.
Key topics are too long to list here (see syllabus above for a full list) but include: PI Toolkit & Foundations, Clinical Trial Design & Protocol Development, Investigator & Team Leadership, Informed Consent & Regulatory Documents, Audits, Adverse Event Reporting & Compliance, Data & Document Management, Global Clinical Trial Mastery, and Medical Devices & Innovation.
The program is fully online and mobile-friendly. It includes interactive case simulations, virtual labs, optional live webinars, regulatory updates, and optional one-on-one mentorship.
Mentorship is included in the PI Executive Fellowship™ tier. You’ll receive six 1:1 private sessions, protocol design review, and two strategic growth consults.
Options include:
• PI Masterclass™ – $1,499 (or 3 x $500)
• PI Executive Fellowship™ – $2,499 (or 10 x $500)
• Organizational Licensing – $5,000/year
Yes. We offer in-house split payments (e.g., 3 x $500) and financing via Klarna and Affirm. You can enroll immediately and pay over time.
You have access to 24/7 technical support, mentorship (depending on tier), and a private student forum for peer and expert discussions.
The certification exam includes 50 multiple-choice questions based on the study guide. A passing score of 70% is required, and two attempts are included.
Yes. A downloadable 50+ page study guide is provided, summarizing all core modules to help you prepare efficiently for the final exam.
You have up to two attempts to pass. Most learners succeed on their first attempt with the help of the study guide.
Yes. You’ll receive lifetime access to the full course, including all future updates, webinars, and bonus modules.
Yes. Every enrollment includes one free Clinical Research Coordinator (CRC) training seat to ensure your site team is trained and aligned.
This course strengthens your feasibility assessments, site performance, and documentation—ensuring you become an audit-ready, compliant PI trusted by sponsors with the knowledge to support your site.
Graduates have reported salary increases of $39K–$259K+ and secured roles such as Senior Clinical Investigator, Clinical Research Director, and more.
Yes. ARPIC is built on FDA, ICH E6(R2), E8, EMA, and global regulatory frameworks, making it suitable for U.S. and international trials.
Yes. You’ll receive downloadable templates for delegation logs, protocol tools, audit prep checklists, visit reports, and more.
Yes. Your certificate, transcript, and completed modules meet sponsor and IRB expectations for PI training and ISF documentation.
Yes. You can access a free preview module before full enrollment to see if the format and content match your needs.
Graduates have transitioned into roles such as Principal Investigator, Senior Research Investigator, Clinical Research Director, Lead Investigator at academic and private institutions, and more.
Yes. All enrollments come with a 14-day money-back guarantee. If the course doesn’t meet your expectations, you’ll receive a full refund.
Scroll above and choose your preferred tier. Once enrolled, you’ll receive instant access to the course dashboard, study guide, and first lessons.
